Given the prevalence and the side effects associated with more traditional medications, it’s no surprise that people are looking for alternative treatments like CBD where it is shown to interact with the body’s endocannabinoid system, impacting various receptors such as serotonin and dopamine. CBD also works to prevent the re-uptake of these neurotransmitters, thus reducing attentiveness levels.
Anxiousness is linked to low levels of serotonin in the brain (serotonin is a neurotransmitter that helps regulate mood), CBD has shown to help by activating a serotonin receptor called 5-HT1A, which increases serotonin levels in the brain. Because CBD acts also as an A2A inhibitor, taking CBD can result in clarity and an elevated mood. Lastly, Anandamide is responsible for feelings of joy and CBD acts as an inhibitor, which can increase the amount available in our brain thereby decreasing the negative effects on your motivation.
The inflammation that occurs in the brain also provokes a release of oxygen. As the oxygen levels within the brain cells rise, functions such as memory decrease. In studies, CBD being an antioxidant and has shown to reduce this effect. The brain cell count in people often showed to undergo a steady decline, reducing cognitive function and leaving destroyed pathways in their wake. CBD has also been shown in studies to not only prevent the destruction of brain cells, but promote regrowth, or neurogenesis.
CBD has been shown to inhibit the immune responses that cause the inflammation that triggers many major digestive conditions without producing a lot of severe side effects like those associated with the pharmaceutical medications. CBD has also been shown to improve the gastrointestinal system’s function with regards to absorbing nutrients. In a digestive study using CBD, over twenty patients that didn’t respond to steroids or immunomodulators took it for about eight weeks to research its effects. Three of the eleven patients who had received the CBD, as opposed to just receiving a placebo, were no longer dependant on steroids and five test subjects even reported complete remission. Furthermore, overall improved symptoms were reported in ten of the eleven patients and all eleven experienced improved appetite and sleep with no significant side effects.
CBD interacts with the CB1 and CB2 cannabinoid receptors in the brain and central nervous system in a way that helps the body rebalance and reach a state of homeostasis, and may be able to bring some stability to your mood. CBD also increases the amount of neurotransmitter anandamide commonly called the “bliss molecule” because it is responsible for feelings of joy, happiness, and motivation. Activation of this receptor also has been shown to decrease behaviors that are prompted by adverse memories. Finally, CBD inhibits the reuptake of the neurotransmitter adenosine, these receptors play an important role in the expression of your mood. When too little adenosine is present in your brain, you may experience mood symptoms. CBD inhibits these specifically, leading to increased amounts of the neurotransmitter in the brain, resulting in an elevated mood.
CBD targets CB1 and CB2 receptors located in the brain and central nervous system. CBD does not directly bind with these receptors, but has an indirect effect on them and other receptors related to managing the symptoms associated with epilepsy. In three different studies involving people with Dravet syndrome and Lennox-Gastaut syndrome (two of the most severe forms of epilepsy), CBD significantly reduced the frequency of seizures. In the case of Dravet syndrome, convulsive tonic-clonic, tonic, clonic, and atonic seizures were reduced while those with Lennox-Gastaut syndrome saw a reduction in drop seizures. After seeing the results of the studies mentioned above, the advisory committee for the United States Food and Drug Administration (FDA) recommended that the pharmaceutical-grade CBD-based medication known as Epidiolex be approved for use in the treatment of epilepsy in 2018.
It is thought that CBD oil reduces the experience of nausea by impacting the 5HT1A or serotonin receptors in the brain, which are thought to cause nausea and vomiting. When CBD binds to these receptors, signals to reduce serotonin production are sent to the forebrain. By blocking the release of serotonin, CBD is able to stop nausea at its source. A study on CBD’s effect on anticipatory nausea specifically showed promising results for this issue, test subjects were exposed to cues while vomiting was induced to create a cognitive connection between the two and when they were given CBD before being exposed to the same cues that were tied to episodes of nausea and vomiting, they did not experience anticipatory nausea.
Everyone has a cell-signaling system known as the endocannabinoid system (ECS). Some researchers think that CBD interacts with a core component of the ECS – endocannabinoid receptors in your brain and immune system. Receptors are tiny proteins attached to your cells. They receive signals, mostly chemical ones, from different stimuli and help your cells respond. This response creates pain-relieving effects that help with pain management. This means that CBD products may benefit people with chronic pain, such as arthritis, back pain, and chronic pain. Try CBD Pain Rub
If you rely on blood pressure medication and want to use CBD as an alternative or supplement to your current treatment plan, studies have shown that it has been suggested that CBD may affect the efficacy of blood pressure medication in controlling hypertension. An important thing to know is that CBD has shown to reduce blood pressure on its own, when it is taken in tandem with medication designed to perform the same action, you essentially have two compounds bringing down your levels. A 2017 study found that a single dose of cannabidiol significantly lowered the blood pressure of test subjects both when at rest and in stressful conditions and may be useful as a treatment for various cardiovascular disorders, such as hypertension, myocardial infarction, and stroke.
CBD affects the body’s CB2 receptors very positively and can help regulate inflammatory responses. In fact, chronic inflammation has been shown to play a significant role in the development and progression of many diseases, indicating that normal CB2 function is not only crucial for reducing inflammation, but also for staying healthy.What makes CBD so effective is its ability to address the mechanisms and processes in the body that cause inflammation and irregular CB2 function in the first place. CBD acts as an adenosine reuptake inhibitor, meaning it helps to increase the amount of adenosine in the brain, which in turn impacts adenosine receptors. Studies have shown that the effect on these receptors, particularly the A2A receptor, plays a significant role in reducing inflammation in the body. Try CBD Pain Rub
The immune system, when functioning properly, is what keeps humans healthy and enables the body to fight disease and infection. CBD can affect the immune system by inhibiting the reuptake of the neurotransmitter adenosine. Through this action, the amount of adenosine in the brain is increased, influencing the A2A adenosine receptors in such a way that it betters the immune system throughout the body. Also, within the endocannabinoid system, CB2 is the one receptor that plays a key role in regulating immune responses, CBD inhibits the CB2 receptor, which then helps regulate the body’s immunity. According to the research, CBD can address autoimmune disorders by calming a hyperactive immune system, and strengthening a compromised one.
Because CBD can reduce some of your issues, it may help eliminate the mental roadblocks keeping you from a good night’s sleep. In a 2019 study, researchers wanted to see if cannabidiol had any effect on over seventy people with sleep conditions. By the end of the three-month study, patients had been taking CBD daily and reported an almost 67% improvement to their sleep scores. In a 2014 study, CBD was shown to reduce the symptoms and movement associated with RBD, resulting in a more restful and restorative sleep for the test subjects.
Because of its known pain-relieving abilities, anti-nausea effects, and minimal side effects, the use of CBD oil for migraine headaches is growing in popularity. Inflammation is a common problem in headaches, which makes CBD oil a useful option. CBD impact the CB2 receptors located in the immune cells which can reduce inflammatory responses, mitigating some of the troubles associated with headaches. A 2016 study into the use of CBD on headaches prevalence followed over a hundred adults over the course of a month, the results found that with the CBD use, the frequency of attacks was reduced from ten to four per month. Furthermore, the participants reported that not only was CBD effective at preventing against headaches but it was also effective at stopping them once they had already begun. Try CBD Pain Rub
CBD has many potential uses, inflammation and pain relief are among the most heavily researched. There are numerous studies that have found CBD to offer promising results for those suffering from painful joints, specifically. In 2006, a study was performed on patients with rheumatoid arthritis (RA). Patients were given CBD and by the end, it was found to offer significant relief. In a 2011 study, CBD showed ro reduce inflammatory pain in subjects with acute arthritis. It was believed that the CBD could target and regulate the receptors that trigger arthritis pain and inflammation. In another study, CBD showed promise as a treatment for osteoarthritis. When CBD was administered at the point of osteoarthritis, it reduced current pain and also blocked future inflammatory flares from progressing the disease. Finally, in a 2016 study, researchers found that a topical preparation of CBD could potentially relieve inflammation and pain brought on by arthritis. The final results stated that the transdermal CBD gel significantly reduced joint swelling and limb posture scores. Try CBD Pain Rub
CBD can offer relief from spasticity because its main ingredient cannabidiol is one of over a hundred phytocannabinoids found in the hemp plant that it is able to act on your endocannabinoid system in a way that reduces the intensity and frequency of your muscle spasms. Also, CBD contains two anti-inflammatory substances that have been shown to act as muscle relaxants. Lastly, CBD can help to reduce cortisol levels, turning down tension and protecting your body from the negative effects that this stress hormone can have on your physical and mental capacities. In a 2004 study in Switzerland, examiners looked at the CBD effect on multiple sclerosis. Researchers concluded that a standardized CBD extract can lower spasm frequency and increase mobility. In 2010, a similar study took place at The University of California. The results showed an average reduction of almost three points on the Modified Ashworth scale (used to measure spasticity in multiple sclerosis patients) as compared to a placebo. Try CBD Pain Rub
Because CBD has been shown to impact multiple receptors and neurotransmitters in the body, it can reduce stress and emotional distress through neuroregeneration, cortisol regulation, and the stimulation of neurotransmitters. CBD has also shown to be an anti-catabolic, which means it can regulate the amount of cortisol released into your system. By regulating cortisol, CBD helps reduce the experience of stress and distress and its after-effects. Many studies examining CBD’s effect have seen success with lowering anxiousness, reducing panic, releasing negative associations, and relieving stress.
CBD (Cannabidiol) has shown to have many positive results on numerous health and wellness conditions. These ailments have seen CBD benefits from studies and users. Some of the health conditions include CBD for colitis, CBD for depression, CBD for epilepsy, CBD for high blood pressure, CBD for IBS, CBD for insomnia, CBD for inflammation, CBD for muscle spasms.
Statements not evaluated by the FDA and are not intended to diagnose, treat, or cure any disease.